Publications

Selected Publications

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Grohar PJ, Heise R, Wedekind MF, Ballman K, Mascarenhas L, DuBois SG, Maki RG, Boguslawski EA, Gedminas JM, Wilson ER, Thomas E, Segers B, Surrey LF, Ricker C, Klega K, Navid F, Lam GY, The S, Kaufman R, Roberts RD, Hayashi M, Mena E, Overman L, Peer C, Schmidt K, Diamond MS, Figg WD, Bagatell R, Liza Lindenberg M, Choyke PL, Crompton BD, Widemann BC, Glod JW, Laetsch TW, Reinke DK, Chugh R. Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial. Nat Med. 2026 Apr 16;. doi: 10.1038/s41591-026-04340-7. PubMed PMID: 41991689.

Neczypor EW, Reisert H, Moore K, Zeldin E, Dubin RA, Battle L, He C, Hayashi M, Weiser DA, Applebaum MA. 5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcoma. NPJ Precis Oncol. 2026 Feb 11;10(1). doi: 10.1038/s41698-026-01326-z. PubMed PMID: 41673231; PubMed Central PMCID: PMC13004888.

Kuo C, Giannikou K, Wang N, Warren M, Goodspeed A, Shillingford N, Hayashi M, Raredon MSB, Amatruda JF. Spatial Profiling Identifies Tumor-Associated Stroma Enrichment and MIF as Potential Immunotherapy Targets in Primary Ewing Sarcomas. Clin Cancer Res. 2025 Dec 1;31(23):5051-5069. doi: 10.1158/1078-0432.CCR-25-0635. PubMed PMID: 40986513; PubMed Central PMCID: PMC12700766.

Offenbacher R, Jackson KW, Hayashi M, Zhang J, Peng D, Tan Y, Stewart TM, Ciero P, Foley J, Casero RA Jr, Cahan P, Loeb DM. Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis. Clin Cancer Res. 2025 Oct 1;31(19):4196-4210. doi: 10.1158/1078-0432.CCR-24-1778. PubMed PMID: 40705089; PubMed Central PMCID: PMC12411968.

Kastner L, Kandalaft W, Mahant AM, Crimella J, Hakim S, Peng XP, Isakoff MS, Hayashi M, Loeb DM. Cytokine Profiling of Children, Adolescents, and Young Adults Newly Diagnosed with Sarcomas Demonstrates the Role of IL-1β in Osteosarcoma Metastasis. Cancers (Basel). 2025 Sep 15;17(18). doi: 10.3390/cancers17183009. PubMed PMID: 41008853; PubMed Central PMCID: PMC12468999.

Taylor AM, Sheng J, Ng PKS, Harder JM, Kumar P, Ahn JY, Cao Y, Dzis AM, Jillette NL, Goodspeed A, Bodlak A, Wu Q, Isakoff MS, George J, Grassmann JDS, Luo D, Flynn WF, Courtois ET, Robson P, Hayashi M, Paolillo AT, Petrilli AS, Caminada de Toledo SR, Balarezo FS, Lindsay AD, Hoang B, Wong STC, Lau CC. Immunosuppressive Tumor Microenvironment of Osteosarcoma. Cancers (Basel). 2025 Jun 24;17(13). doi: 10.3390/cancers17132117. PubMed PMID: 40647416; PubMed Central PMCID: PMC12248827.

Goodspeed A, Bodlak A, Duffy AB, Nelson-Taylor S, Oike N, Porfilio T, Shirai R, Walker D, Treece A, Black J, Donaldson N, Cost C, Garrington T, Greffe B, Luna-Fineman S, Demedis J, Lake J, Danis EP, Verneris M, Adams DL, Hayashi M. Single cell RNA-sequencing of Ewing sarcoma tumors demonstrates transcriptional heterogeneity and clonal evolution. Clin Cancer Res. 2025 Mar 3;. doi: 10.1158/1078-0432.CCR-24-2040. [Epub ahead of print] PubMed PMID: 40029262.

Dhir A, Hayashi M, Bodlak A, Oesterheld J, Loeb DM, Mascarenhas L, Isakoff MS, Sandler ES, Borinstein SC, Trucco M, Lagmay JP, Setty BA, Pratilas CA, Caywood E, Metts J, Yin H, Fridley B, Yin J, Laborde J, Reed DR, Adams DL, Wagner LM. Phase II Trial of Gemcitabine and Nab-Paclitaxel for Recurrent Osteosarcoma with Serial Monitoring Using Liquid Biopsy: A Report from the National Pediatric Cancer Foundation. Clin Cancer Res. 2024 Dec 2;30(23):5314-5322. doi: 10.1158/1078-0432.CCR-24-1339. PubMed PMID: 39360936.

Shirai R, Biebighauser T, Walker D, Oviedo J, Nelson-Taylor S, Bodlak A, Porfilio T, Oike N, Goodspeed A, Hayashi M. Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma. PLoS One. 2024;19(6):e0305490. doi: 10.1371/journal.pone.0305490. eCollection 2024. PubMed PMID: 38875295; PubMed Central PMCID: PMC11178195.

Shulman DS, Whittle SB, Surdez D, Bailey KM, de Álava E, Yustein JT, Shlien A, Hayashi M, Bishop AJR, Crompton BD, DuBois SG, Shukla N, Leavey PJ, Lessnick SL, Kovar H, Delattre O, Grünewald TGP, Antonescu CR, Roberts RD, Toretsky JA, Tirode F, Gorlick R, Janeway KA, Reed D, Lawlor ER, Grohar PJ. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma. NPJ Precis Oncol. 2022 Sep 17;6(1):65. doi: 10.1038/s41698-022-00307-2. Review. PubMed PMID: 36115869; PubMed Central PMCID: PMC9482616.

Bodlak A, Chang K, Channel J, Treece AL, Donaldson N, Cost CR, Garrington TP, Greffe B, Luna-Fineman S, Sopfe J, Loeb DM, Hayashi M. Circulating Plasma Tumor DNA Is Superior to Plasma Tumor RNA Detection in Ewing Sarcoma Patients: ptDNA and ptRNA in Ewing Sarcoma. J Mol Diagn. 2021 Jul;23(7):872-881. doi: 10.1016/j.jmoldx.2021.04.003. Epub 2021 Apr 20. PubMed PMID: 33887462; PubMed Central PMCID: PMC8261897.

Nellan A, Bodlak A, Mirsky DM, Mulcahy Levy J, Garrington TP, Foreman NK, Gilani A, Hayashi M. ddPCR Analysis Reveals BRAF V600E Mutations Are Infrequent in Isolated Pituitary Langerhans Cell Histiocytosis Patients. J Neuropathol Exp Neurol. 2020 Dec 4;79(12):1313-1319. doi: 10.1093/jnen/nlaa091. PubMed PMID: 32930721; PubMed Central PMCID: PMC8453605.

Brechbuhl HM, Vinod-Paul K, Gillen AE, Kopin EG, Gibney K, Elias AD, Hayashi M, Sartorius CA, Kabos P. Analysis of circulating breast cancer cell heterogeneity and interactions with peripheral blood mononuclear cells. Mol Carcinog. 2020 Oct;59(10):1129-1139. doi: 10.1002/mc.23242. Epub 2020 Aug 21. PubMed PMID: 32822091; PubMed Central PMCID: PMC7895311.

Hayashi M, Baker A, Goldstein SD, Albert CM, Jackson KW, McCarty G, Kahlert UD, Loeb DM. Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma. Oncotarget. 2017 Oct 3;8(45):78265-78276. doi: 10.18632/oncotarget.19432. eCollection 2017 Oct 3. PubMed PMID: 29108227; PubMed Central PMCID: PMC5667961.

Hayashi M, Zhu P, McCarty G, Meyer CF, Pratilas CA, Levin A, Morris CD, Albert CM, Jackson KW, Tang CM, Loeb DM. Size-based detection of sarcoma circulating tumor cells and cell clusters. Oncotarget. 2017 Oct 3;8(45):78965-78977. doi: 10.18632/oncotarget.20697. eCollection 2017 Oct 3. PubMed PMID: 29108279; PubMed Central PMCID: PMC5668012.

Hayashi M, Chu D, Meyer CF, Llosa NJ, McCarty G, Morris CD, Levin AS, Wolinsky JP, Albert CM, Steppan DA, Park BH, Loeb DM. Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA. Cancer. 2016 Oct;122(19):3015-23. doi: 10.1002/cncr.30144. Epub 2016 Jun 28. PubMed PMID: 27351911; PubMed Central PMCID: PMC5102400.

Goldstein SD, Hayashi M, Albert CM, Jackson KW, Loeb DM. An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. Clin Exp Metastasis. 2015 Oct;32(7):703-15. doi: 10.1007/s10585-015-9738-x. Epub 2015 Aug 18. PubMed PMID: 26278104.

Link for all publications: https://www.ncbi.nlm.nih.gov/myncbi/masanori.hayashi.2/bibliography/public/