Welcome to the Hayashi Lab

The main goal of the Hayashi lab is to find more effective ways to treat metastatic sarcomas in children. While the historic induction of intensive chemotherapy in the 70’s to 80’s improved the cure rate for many children with localized sarcomas, progress has stalled in the past 3 decades. The pattern of recurrence and treatment failure is almost exclusively due to metastatic recurrence, highlighting a major limitation of the current therapeutic approach. This has led to the overarching theme of our lab, to identfy metastasis-specific biology that leads to treatment resistance, and to specifically develop anti-metastasis therapies. 

Our lab aims to identify and validate novel therapeutic strategies for pediatric sarcomas through in vitro and in vivo preclinical models. We also seek to improve therapeutic strategies through better risk stratification and minimal residual disease detection through liquid biopsies.